Rallies in several Egyptian cities after businessman Mohamed Ali accused el-Sisi of corruption, called for resignation.
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Thousands of pro-democracy protesters marched in cities across Egypt on Friday, demanding the resignation of President Abdel Fattah el-Sisi.
Videos posted on social media showed demonstrators chanting "rise up, fear not, Sisi must go" and "the people demand the regime's fall" late on Friday.
Protests were reported in the capital Cairo, the second-biggest city of Alexandria and Suez.
Officers in civilian uniforms confronted the demonstrators who tried approaching Cairo's Tahrir Square, where mass protests started in 2011 which toppled Hosni Mubarak.
Al Jazeera is banned from reporting from inside Egypt, but there were several reports of arrests made in the capital, and tear gas being used on demonstrators.
The demonstrations came after self-exiled Egyptian businessman and actor Mohamed Ali accused President el-Sisi of corruption and called on people to take to the streets and demand the leader be removed. El-Sisi has dismissed the allegations as "lies".
"If el-Sisi does not announce his resignation by Thursday, then the Egyptian people will come out to the squares on Friday in protest," Ali said in a video posted on Tuesday.